Protein Details: Neuronal acetylcholine receptor subunit alpha-6

Protein ID

ICDB_Pro_1615

Protein Name

Neuronal acetylcholine receptor subunit alpha-6

Gene Name

Chrna6; Nica6

Organism

Mus musculus (Mouse)

Length

494 amino acids

AlphaFoldDB

AF-Q9R0W9-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. .

Sequence

MLNSRDQGNLHSGLCLWLCGFLALFKGSTGCESEEQLFHRLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHIWKDYRLRWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTIFLQAFPSILMMRKPLDKTKEAGGVKDPKSHTKRPAKVKFTHRGESKLLKECHHCQKSSDIAPGKRRSSQQPARWVAENSEHSSDVEDVIESVQFIAENMKSHNETNEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGKS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 84: "Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site"; SITE 136: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"; SITE 144: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"

Disease

Location

DOI ID

10.1097/00008571-200106000-00008; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504

RefSeq

NP_033732.2